Seesmic    FREE

If you use Twitter and Facebook - or better yet, if you DON’T because you think its too hard, then you need Seesmic Desktop. Seesmic is a centralized dashboard for your Twitter and Facebook activities.

You can add favorites, retweet, reply, direct comment, post pictures, even add a video using webcam.

If you have multiple Twitter accounts - one for personal one for business perhaps - you can view all your twitter activities together or by account.  

Search for topics, follow/un-follow, shrink text, and view and enter comments quickly.

Why its good:

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One centralized place to view and manage your Twitter and Facebook Activities

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Makes it easier for people who are new to social media

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Its FREE